Seizures risk factors in sickle cell disease. The cooperative study of sickle cell disease

IntroductionAlthough evidence suggests that neurological complications, including seizures and epilepsy, are more common among sickle cell disease (SCD) patients, few studies have assessed the risk factors of developing SCD patientsMethodsWe used a nested case–control study design to compare pediatric adult patients who experienced with did not experience any seizure regarding clinical laboratory parameters. We conducted secondary analysis using data from Cooperative Study Sickle Cell Disease in this studyResultsThere were 153 out 2804 (5.5%) had median age 8.5 (Interquartile range [IQR] = 10.1) years at first 115 1281 (9.0%) 28.0 (IQR 10.6) seizure. Cerebrovascular accident ([CVA], OR 5.7, 95% CI 2.9–11.0), meningitis (OR 3.6, 1.8–7.2), eye 3.4, 1.5–8.0) associated increased patients. While CVA 7.5, 3.5–16.0), 5.6, 1.5–20.0), nephrotic syndrome 3.0, 1.2–7.9), spleen sequestration 2.7, 1.1–6.3), pneumonia 2.1, 1.0–4.4) patientsConclusionThese findings suggest need for treatment optimization regular follow up these identified prevent development seizures.